Design of a randomized controlled trial examining the efficacy and biological mechanisms of Web-Prolonged Exposure and Present-Centered Therapy for PTSD among active-duty military personnel and veterans.

McLean, C. P., Rauch, S. A. M., Foa, E. B., Sripada, R. K., Tannahill, H. S., Mintz, J., Yarvis, J., Young-McCaughan, S., Dondanville, K. A., Hall-Clark, B. N., Fina, B. A., Keane, T., & Peterson, A. L., for the STRONG STAR Consortium and the Consortium to Alleviate PTSD.
Jan 1, 2018

Contemporary Clinical Trials, 64(1), 41-48.

Improved accessibility of effective and efficient evidence-based treatments (EBTs) for military personnel suffering with posttraumatic stress disorder (PTSD) is an urgent need to meet the growing demand for timely care. In addition, a better understanding of the mechanism of action of behavioral therapy can inform the delivery of care to meet accessibility demands. Effective EBTs for PTSD are available, but logistical and stigma-related barriers to accessing behavioral healthcare can deter military personnel from receiving these treatments. Web-based treatments represent an innovative way to overcome these barriers. The efficacy of previously developed web-based treatments for PTSD appears promising; however, they were not developed based on treatment protocols with strong empirical support for their efficacy. No study to date has examined web-based treatment of PTSD using a well-established evidence-based treatment, nor delineated the biological mechanisms through which a web-based treatment exerts its effects. This paper describes the rationale and methods of a randomized controlled trial comparing the efficacy and potential biological mediators of 10 sessions of a web-version of Prolonged Exposure (PE), “Web-PE,” delivered over 8 weeks compared to 10 sessions of in-person Present-Centered Therapy (PCT) delivered over 8 weeks by a therapist in 120 active duty military personnel and veterans with PTSD.

Find the article through the link: